BDBM428677 (R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-3-methyl-3- (tetrahydro-2H-pyran-4- yl)indolin-2-one::US10544147, Compound 1-34::US10544147, Compound 1-35

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C(C)(C3CCOCC3)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=PUPVZWZQJDIJPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428677   

LigandPNGBDBM428677(US10544147, Compound 1-35 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 5nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428677(US10544147, Compound 1-35 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 48nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent