BDBM428723 (R or S)-3-((5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-3-methyl-2- oxoindolin-3-yl)amino)- 2,2-dimethylpropanenitrile::US10544147, Compound 2-39::US10544147, Compound 2-40

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C(C)(NCC(C)(C)C#N)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=DURFABJLDNKYFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428723   

LigandPNGBDBM428723((R or S)-3-((5-(9-ethyl-8-(2- methylpyrimidin-5-yl...)
Affinity DataIC50: 3nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428723((R or S)-3-((5-(9-ethyl-8-(2- methylpyrimidin-5-yl...)
Affinity DataIC50: 179nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent