BDBM428755 (R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-3-(((3- fluorooxetan-3- yl)methyl)amino)-3- methylindolin-2-one::US10544147, Compound 2-71::US10544147, Compound 2-72

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C(C)(NCC3(F)COC3)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=VQGRMRNBGZTLBM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428755   

LigandPNGBDBM428755(US10544147, Compound 2-72 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 3nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428755(US10544147, Compound 2-72 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 219nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent