BDBM428776 (R or S)-1'- (cyclopropanecarbonyl)-1- ethyl-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)spiro[indoline-3,2'- pyrrolidin]-2-one::US10544147, Compound 3-9

SMILES CCN1C(=O)C2(CCCN2C(=O)C2CC2)c2cc(ccc12)-c1ncnc2n(CC)c(nc12)-c1cnc(C)nc1

InChI Key InChIKey=GUKUFQVQTSBLGA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 428776   

LigandPNGBDBM428776(US10544147, Compound 3-9 | (R or S)-1'- (cycloprop...)
Affinity DataIC50: 5nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent