BDBM428778 (R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-1''- isopropylspiro[indoline- 3,2''-pyrrolidin]-2-one::US10544147, Compound 3-11::US10544147, Compound 3-12

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C3(CCCN3C(C)C)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=ZTFPHVNLMKRBQU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428778   

LigandPNGBDBM428778(US10544147, Compound 3-12 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 3nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent

LigandPNGBDBM428778(US10544147, Compound 3-12 | (R or S)-5-(9-ethyl-8-...)
Affinity DataIC50: 34nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
US Patent