BDBM428783 (R or S)-1'- (cyclopropanecarbonyl)-5- (9-methyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-1-(2- morpholinoethyl)spiro [indoline-3,2'-pyrrolidin]- 2-one::US10544147, Compound 3-16

SMILES Cc1ncc(cn1)-c1nc2c(ncnc2n1C)-c1ccc2N(CCN3CCOCC3)C(=O)C3(CCCN3C(=O)C3CC3)c2c1

InChI Key InChIKey=AMSHEWISARUJGL-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 428783   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Merck Sharp & Dohme

US Patent

LigandBDBM428783(US10544147, Compound 3-16 | (R or S)-1'- (cyclopro...)Copy SMILESCopy InChI

Affinity DataIC50: 2nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/2/2020
Entry Details
Copy BDB DOIUS Patent

Copy reaction URL