BDBM429524 4-[2-(4-dimethylamino-piperidin-1- yl)- 1-methyl-5-(1-methyl-1H-indazol-5- yl)-6-oxo-1,6-dihydro-pyrimidin-4-yl]- 2-fluoro-benzonitrile::US10548896, Example 72

SMILES CN(C)C1CCN(CC1)c1nc(-c2ccc(C#N)c(F)c2)c(C2=CC3C=NN(C)C3C=C2)c(=O)n1C

InChI Key InChIKey=UPHWMQUDGPQGNP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 429524   

TargetLysine-specific histone demethylase 1A(Human)
Celgene Quanticel Research

US Patent
LigandPNGBDBM429524(4-[2-(4-dimethylamino-piperidin-1- yl)- 1-methyl-5...)
Affinity DataIC50: 100nMAssay Description:This assay determines the ability of a test compound to inhibit LSD-1 demethylase activity. E. coli expressed full-length human LSD-1 (Accession numb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
US Patent