BDBM429814 (Z)-N-(3-bromo-4- fluorophenyl)-4-((2,3- dihydroxypropyl)thio)-N''- hydroxy-1,2,5-oxadiazole-3- carboximidamide::US10538497, Example 17::US10538497, Example 63::US10538497, Example 64

SMILES OCC(O)CSc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O

InChI Key InChIKey=GWSLNDIQSUMPKZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 429814   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM429814(US10538497, Example 63 | US10538497, Example 64 | ...)
Affinity DataIC50: 34.8nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 uM delta aminolevulin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM429814(US10538497, Example 63 | US10538497, Example 64 | ...)
Affinity DataIC50: 46.1nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 uM delta aminolevulin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM429814(US10538497, Example 63 | US10538497, Example 64 | ...)
Affinity DataIC50: 49.1nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 uM delta aminolevulin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2020
Entry Details
US Patent