BDBM430329 US10556900, Compound 11

SMILES CC(C)(O)c1cnc2c(NC(=O)c3cc(-c4ncccn4)c(cc3F)C(F)(F)F)c(ccn12)-c1ccccc1

InChI Key InChIKey=AUMNOXYSMUQVLA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430329   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430329(US10556900, Compound 11)
Affinity DataIC50: 4nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent