BDBM430354 US10556900, Compound 36

SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2c(ccc3c(cnn23)C(C)(C)O)-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key InChIKey=IKAQDMGMENMIOU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 430354   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM430354(US10556900, Compound 36)
Affinity DataIC50: 0.400nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2020
Entry Details
US Patent