BDBM431875 US10550114, Compound 30

SMILES Clc1ccc(NC(=O)NC2CCN(Cc3ccc(cc3)-c3nc4cc[nH]c(=O)c4cc3-c3ccccc3)CC2)cc1NC(=O)C=C

InChI Key InChIKey=LRGXTKXODXMFAS-UHFFFAOYSA-N

Data  1 KI  3 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 431875   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataIC50: 6nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataIC50: 8.90nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataIC50: 9.10nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataKi:  18nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataKi:  18.9nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataKd:  468nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase [E17K](Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431875(US10550114, Compound 30)
Affinity DataIC50: 1.95E+3nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent