BDBM431886 US10550114, Compound 50

SMILES C=CC(=O)Nc1ccc(cc1)C(=O)NC1CCN(Cc2ccc(cc2)-c2nc3cc[nH]c(=O)c3cc2-c2ccccc2)CC1

InChI Key InChIKey=ATOPRMWPARCXGA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 431886   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431886(US10550114, Compound 50)
Affinity DataIC50: 87.6nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431886(US10550114, Compound 50)
Affinity DataIC50: 285nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431886(US10550114, Compound 50)
Affinity DataKi:  362nMAssay Description:Covalent-allosteric inhibition of full length N-terminal his6-tagged AKT (2 to 446 residues) (unknown origin) expressed in Spodoptera frugiperda Sf9 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase [E17K](Human)
Technische UniversitÄT Dortmund

US Patent
LigandPNGBDBM431886(US10550114, Compound 50)
Affinity DataIC50: 2.87E+3nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent