BDBM431975 US10576064, Example I-170::US10576064, Example I-171

SMILES OC(=O)c1ccc(cc1)N1CC[C@H]2[C@H]([C@H](c3cccc(Cl)c3F)[C@@]3(N2CC2CC2)C(=O)Nc2cc(Cl)ccc32)C1=O

InChI Key InChIKey=BVIIEJXEZARDLB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 431975   

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM431975(US10576064, Example I-171 | US10576064, Example I-...)
Affinity DataIC50: 4nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [23-127](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM431975(US10576064, Example I-171 | US10576064, Example I-...)
Affinity DataIC50: 11nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent