BDBM432136 N-(1-Benzylpiperidin-4-yl)-N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]isoxazole-5-::US10577360, Example 3

SMILES Fc1ccc(cc1)-n1ccc(n1)N(C1CCN(Cc2ccccc2)CC1)C(=O)c1ccno1

InChI Key InChIKey=VFFSBBRLZBRQMB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432136   

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432136(US10577360, Example 3 | N-(1-Benzylpiperidin-4-yl)...)
Affinity DataKi:  300nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432136(US10577360, Example 3 | N-(1-Benzylpiperidin-4-yl)...)
Affinity DataKi: >5.00E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent