BDBM432225 N-[1-(4-Cyanophenyl)-1H-pyrazol-3-yl]-N-(1-methylpiperidin-4-yl)thiophene-2-::US10577360, Example 89

SMILES CN1CCC(CC1)N(C(=O)c1cccs1)c1ccn(n1)-c1ccc(cc1)C#N

InChI Key InChIKey=HORLRCMRIBAKMX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432225   

TargetMu-type opioid receptor(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432225(N-[1-(4-Cyanophenyl)-1H-pyrazol-3-yl]-N-(1-methylp...)
Affinity DataKi:  300nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Homo sapiens (Human))
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432225(N-[1-(4-Cyanophenyl)-1H-pyrazol-3-yl]-N-(1-methylp...)
Affinity DataKi:  2.75E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent