BDBM432266 N-[6-(4-Fluorophenyl)pyrazin-2-yl]-N-(1-methylpiperidin-4-yl)thiophene-2-::US10577360, Example 129

SMILES CN1CCC(CC1)N(C(=O)c1cccs1)c1cccc(n1)-c1ccc(F)cc1

InChI Key InChIKey=FHJBELMHYSMBBQ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 432266   

TargetMu-type opioid receptor(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432266(US10577360, Example 129 | N-[6-(4-Fluorophenyl)pyr...)
Affinity DataKi:  300nMAssay Description:To investigate binding properties of test compounds to human μ-opioid receptor, transfected CHO-K1 cell membranes and [3H]-DAMGO (Perkin Elmer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent

TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM432266(US10577360, Example 129 | N-[6-(4-Fluorophenyl)pyr...)
Affinity DataKi:  2.75E+3nMAssay Description:Human α2δ-1 enriched membranes (2.5 μg) were incubated with 15 nM of radiolabeled [3H]-Gabapentin in assay buffer containing Hepes-KOH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent