BDBM433073 5-cyclopropyl-N-((2R,4R)-1-(((1- methylpiperidin-4-yl)methyl)sulfonyl)-2- propylpiperidin-4-yl)isoxazole-3- carboxamide::US10577363, Compound 777

SMILES CCC[C@@H]1C[C@@H](CCN1S(=O)(=O)CC1CCN(C)CC1)NC(=O)c1cc(on1)C1CC1

InChI Key InChIKey=JCYQUDXDXRUXPF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433073   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM433073(US10577363, Compound 777 | 5-cyclopropyl-N-((2R,4R...)
Affinity DataIC50: 1.14nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2020
Entry Details
US Patent