BDBM433719 1-(4-(1H- pyrazol-4- yl)phenyl)-4- (2,5-difluoro- benzyl)-1H- 1,2,4-triazol-::US10562887, Example 20

SMILES Fc1ccc(F)c(Cn2cnn(-c3ccc(cc3)-c3cn[nH]c3)c2=O)c1

InChI Key InChIKey=DUWRXDSBSPRIRC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433719   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433719(US10562887, Example 20 | 1-(4-(1H- pyrazol-4- yl)p...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent