BDBM433987 1-(3-ethyl-4-(1H- pyrazol-4- yl)phenyl)-4-(3- fluorobenzyl)-3- methyl-1H-1,2,4- triazol-5(4H)-one::US10562887, Example 106

SMILES CCc1cc(ccc1-c1cn[nH]c1)-n1nc(C)n(Cc2cccc(F)c2)c1=O

InChI Key InChIKey=SRIVMOCNGJGBHT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 433987   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM433987(1-(3-ethyl-4-(1H- pyrazol-4- yl)phenyl)-4-(3- fluo...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent