BDBM434018 1-(4-(1H-pyrazol-4- yl)phenyl)-4-(3,5- difluorobenzyl)-3-(2- hydroxypropan-2-yl)- 1H-1,2,4-triazol- 5(4H)-one::US10562887, Example 137

SMILES CC(C)(O)c1nn(-c2ccc(cc2)-c2cn[nH]c2)c(=O)n1Cc1cc(F)cc(F)c1

InChI Key InChIKey=PNBCBTPOJICTAT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 434018   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434018(1-(4-(1H-pyrazol-4- yl)phenyl)-4-(3,5- difluoroben...)
Affinity DataIC50: 27.5nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL, assay containing 20 mM HEPES, pH 7.5, 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent