BDBM434575 US10562900, Example 72

SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc2c(NC(=O)c3ccc(cc3)N3CCNC(C)(C)C3)n[nH]c2n1

InChI Key InChIKey=QNXOYMFBIACDSL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 434575   

LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR1 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR1 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR2 (456 to 770 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FGFR3 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR3 (447 to 761 residues) expressed in baculovirus infected Sf21 cells by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FGFR3 (unknown origin) using Poly (Glu,Tyr) 4:1 as substrate incubated for 60 mins in presence of ATP by ELISA analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1R (unknown origin) incubated for 1 hrs by Z'-LYTE Kinase assay kitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1-R (unknown origin) by Z'-LYTE Kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of CSF1R (unknown origin) in presence of ATP by Z-LYTE based FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal 6his tagged recombinant human FGFR2 N549H mutant (456 to 770 residues) expressed in baculovirus infected Sf21 cells by ELISA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST tagged recombinant human FGFR1 V561M mutant (456 to 765 residues) expressed in baculovirus infected Sf21 cells by ELISA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 51nMAssay Description:Inhibition of FGFR4 (unknown origin) by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 100nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

LigandPNGBDBM434575(US10562900, Example 72)
Affinity DataIC50: 100nMAssay Description:The enzyme reaction substrate Poly(Glu,Tyr) 4:1 was diluted with PBS without potassium ion (10 mM sodium phosphate buffer, 150 mM NaCl, pH7.2-7.4) to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent