BDBM434770 US10562910, Example 1

SMILES OC(=O)c1ccc2c(Oc3ccc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)nc3C=C2F)c1

InChI Key InChIKey=FLCKGOOCCIMGCT-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 434770   

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434770(US10562910, Example 1)
Affinity DataEC50:  17nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434770(US10562910, Example 1)
Affinity DataEC50:  49.3nMAssay Description:Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434770(US10562910, Example 1)
Affinity DataEC50:  219nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed