BDBM434773 US10562910, Example 13

SMILES CC1Cc2ccc(cc2Oc2ccc(OCc3c(onc3-c3c(Cl)cccc3Cl)C3CC3)nc12)C(O)=O

InChI Key InChIKey=ZSGKCBJKVYQMFL-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 434773   

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434773(US10562910, Example 13)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434773(US10562910, Example 13)
Affinity DataEC50:  5.40nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434773(US10562910, Example 13)
Affinity DataEC50:  19.5nMAssay Description:Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent