BDBM434776 US10562910, Example 5

SMILES OC(=O)c1ccc2C=C(F)c3nc(OCc4c(onc4-c4c(Cl)cccc4Cl)C4CC4)ccc3Oc2c1

InChI Key InChIKey=BBESGANVRPQFJB-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 434776   

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434776(US10562910, Example 5)
Affinity DataEC50:  4.80nMAssay Description:Agonist activity at FXR-LBD (unknown origin) assessed as induction of coactivator SRC-1 peptide recruitment measured by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434776(US10562910, Example 5)
Affinity DataEC50:  25.7nMAssay Description:Purchasing invitrogen PV4833 kits. The procedure refers to LanthaScreen TR-FRET Farnesoid X Receptor Coactivator AssayFirst, the required amount of t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2020
Entry Details
US Patent

TargetBile acid receptor(Human)
Southern Medical University Biomedical Research Center

Curated by ChEMBL
LigandPNGBDBM434776(US10562910, Example 5)
Affinity DataEC50:  102nMAssay Description:Agonist activity at human FXR expressed in HEK293T cells by luciferase reporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed