BDBM434863 7-[14-(Trifluoromethoxy)-18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,16]pentacosa-1(23),4,6(25),12,14,16::US10577383, Example 23

SMILES Nc1cc(C2CCNCc3cc(COc4cccc(Cn5cc2cn5)c4)cc(OC(F)(F)F)c3)c2nn[nH]c2n1

InChI Key InChIKey=FYFDCZJFHJFBDG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 434863   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434863(US10577383, Example 23 | 7-[14-(Trifluoromethoxy)-...)
Affinity DataIC50: 550nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434863(US10577383, Example 23 | 7-[14-(Trifluoromethoxy)-...)
Affinity DataIC50: 5.50E+3nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent