BDBM434871 7-[(3S,4S)-4-Benzyl-2-oxa-6,12,13-triazatetracyclo[13.3.1.13,6.110,13]henicosa-1(18),10(20),11,15::US10577383, Example 31

SMILES Nc1cc(C2CCN3C[C@H](Cc4ccccc4)[C@@H](C3)Oc3cccc(Cn4cc2cn4)c3)c2nn[nH]c2n1

InChI Key InChIKey=WHOPNONEBDNGIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 434871   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434871(US10577383, Example 31 | 7-[(3S,4S)-4-Benzyl-2-oxa...)
Affinity DataIC50: 50nMAssay Description:MPO chlorination activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Aminophenyl fluorescein (APF, Invitrogen Cat. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM434871(US10577383, Example 31 | 7-[(3S,4S)-4-Benzyl-2-oxa...)
Affinity DataIC50: 550nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen Cat. #A12222) which can...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
US Patent