BDBM435140 3-fluoro-4-(1-(3- fluoro-2-methyl-6-(1- (trifluoromethyl)cyclo- propyl)benzoyl)-1H- pyrazolo[4,3- b]pyridin-3- yl)benzoic acid::US10584121, Example 1I

SMILES Cc1c(F)ccc(c1C(=O)n1nc(-c2ccc(cc2F)C(O)=O)c2ncccc12)C1(CC1)C(F)(F)F

InChI Key InChIKey=PRBNXYZWCBGOFY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435140   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435140(US10584121, Example 1I | 3-fluoro-4-(1-(3- fluoro-...)
Affinity DataIC50: 2.40nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
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Date in BDB:
11/29/2020
Entry Details
US Patent