BDBM435306 8-(((trans)-2-(3-methyl-1,2,4-oxadiazol-5- yl)cyclopropanecarboxamido)methyl)-N- (3-methyloxetan-3-yl)-5-(3- (trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2(1H)-carboxamide (mixture of 2 isomers)::US10568876, Example 69

SMILES Cc1noc(n1)[C@@H]1C[C@H]1C(=O)NCc1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC1(C)COC1

InChI Key InChIKey=PLDRQUONBDVJCZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435306   

TargetDiacylglycerol O-acyltransferase 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM435306(US10568876, Example 69 | 8-(((trans)-2-(3-methyl-1...)
Affinity DataIC50: 19.6nMAssay Description:DGAT2 activity was determined by measuring the amount of enzymatic product triolein (1,2,3-Tri(cis-9-octadecenoyl)glycerol) using the membrane prep m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent