BDBM435675 US10570121, Example 181::US10570121, Example 182

SMILES COC(C1CN(C1)C1COC1)c1cc(C)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=AWZJDEMBMKNVAF-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 435675   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 435675BDBM435675(US10570121, Example 182 | US10570121, Example 181)
Affinity DataKi:  1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 435675BDBM435675(US10570121, Example 182 | US10570121, Example 181)
Affinity DataIC50: 41nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 435675BDBM435675(US10570121, Example 182 | US10570121, Example 181)
Affinity DataKi:  2.23E+3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 435675BDBM435675(US10570121, Example 182 | US10570121, Example 181)
Affinity DataIC50: 9.15E+3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent