BDBM435679 US10570121, Example 185::US10570121, Example 186

SMILES Cc1cc(C)c(CN2CCc3c(Cl)cc(C(C)C4CN(S(C)(=O)=O)C4)c(Cl)c3C2=O)c(=O)[nH]1

InChI Key InChIKey=ZHHYRSNUXSFNGW-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 435679   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 435679BDBM435679(US10570121, Example 186 | US10570121, Example 185)
Affinity DataKi:  1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 435679BDBM435679(US10570121, Example 186 | US10570121, Example 185)
Affinity DataIC50: 12nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 435679BDBM435679(US10570121, Example 186 | US10570121, Example 185)
Affinity DataKi:  14nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 435679BDBM435679(US10570121, Example 186 | US10570121, Example 185)
Affinity DataIC50: 240nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent