BDBM435714 US10570141, Example 3

SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3cc(n(C4CCCC4)c3n2)S(C)(=O)=O)nc1

InChI Key InChIKey=AGQLFAHPXTYWNF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 435714   

TargetCyclin-dependent kinase 4(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM435714(US10570141, Example 3)
Affinity DataIC50: 3.40nMAssay Description:LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM435714(US10570141, Example 3)
Affinity DataIC50: 18.7nMAssay Description:LANCE method of PerkinElmer Inc. was used in the assay, and recombinant CDK4/CyclinD3 (Item No.: 04-105) and CDK6/CyclinD3 (Item No.: 04-107) kinases...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent