BDBM435822 US10570167, Cpd. # 140::US10570167, Cpd. # 141::US11034715, Cpd. # 141

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(NC(=O)c3cccs3)cc2)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=CVJWOIUWPVDTNH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 435822   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435822(US10570167, Cpd. # 141 | US10570167, Cpd. # 140 | ...)
Affinity DataIC50: 30nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435822(US10570167, Cpd. # 141 | US10570167, Cpd. # 140 | ...)
Affinity DataIC50: 30nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435822(US10570167, Cpd. # 141 | US10570167, Cpd. # 140 | ...)
Affinity DataIC50: 60nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435822(US10570167, Cpd. # 141 | US10570167, Cpd. # 140 | ...)
Affinity DataIC50: 60nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent