BDBM435853 US10570167, Cpd. # 179::US11034715, Cpd. # 179

SMILES Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](COC(Cc2ccc(cc2)N2CCCNC2=O)(C(O)=O)C(O)=O)[C@@H](O)[C@@H]1F

InChI Key InChIKey=POESURWISNRQEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 435853   

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435853(US10570167, Cpd. # 179 | US11034715, Cpd. # 179)
Affinity DataIC50: 9nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2020
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435853(US10570167, Cpd. # 179 | US11034715, Cpd. # 179)
Affinity DataIC50: 9nMAssay Description:For measurements of soluble CD73 enzyme activity, recombinant CD73 was obtained from R&D Systems, Cat. No. 5795-EN-010. Serial dilutions of test comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2021
Entry Details
US Patent

Target5'-nucleotidase(Human)
Calithera Biosciences

US Patent
LigandPNGBDBM435853(US10570167, Cpd. # 179 | US11034715, Cpd. # 179)
Affinity DataIC50: 9nMAssay Description:Inhibition of human C-terminal 6His-tagged CD73 ( Trp27 to Lys547 residues) expressed in CHO cells using AMP as substrate incubated for 30 mins by ma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2022
Entry Details Article
PubMed