BDBM435917 5-[2-(Cyclopropylmethoxy)-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one;::US10611730, Example 89

SMILES O=c1[nH]c2ccc(-c3c(OCC4CC4)cccc3OC(F)(F)F)cc2[nH]1

InChI Key InChIKey=QROSAFSPYFIYGB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 435917   

TargetVoltage-dependent calcium channel gamma-8 subunit(Human)
Janssen Pharmaceutica

US Patent
LigandChemical structure of BindingDB Monomer ID 435917BDBM435917(US10611730, Example 89 | 5-[2-(Cyclopropylmethoxy)...)
Affinity DataIC50: 3.98nMAssay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent