BDBM436046 2-(2,3-difluorophenyl)-1- ((1S,3R)-3-(hydroxymethyl)-1- methyl-5-(1H-pyrazol-4-yl)- 3,4-dihydroisoquinolin-2(1H)- yl)ethan-1-one::US10611751, Example 14

SMILES C[C@@H]1N([C@@H](CO)Cc2c1cccc2-c1cn[nH]c1)C(=O)Cc1cccc(F)c1F

InChI Key InChIKey=TZSUGUFPRGXMTP-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436046   

TargetD(1A) dopamine receptor(Human)
Eli Lilly

US Patent
LigandPNGBDBM436046(US10611751, Example 14 | 2-(2,3-difluorophenyl)-1-...)
Affinity DataEC50:  677nMAssay Description:The PAM activity of the compounds of the present invention may be measured essentially as described in Svensson et al., An Allosteric Potentiator of ...More data for this Ligand-Target Pair
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Date in BDB:
12/7/2020
Entry Details
US Patent