BDBM436084 (S)-4-amino-6-((1-(3-chloro-6-(o-tolyl)imidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile::US10611777, Compound 31

SMILES COc1ccc(CN(Cc2ccc(OC)cc2)c2cc([C@H](C)NS(=O)C(C)(C)C)c(nn2)-c2ccccc2C)cc1

InChI Key InChIKey=WLDAFMKORBHDLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436084   

LigandPNGBDBM436084(US10611777, Compound 31 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 4nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

LigandPNGBDBM436084(US10611777, Compound 31 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 146nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM436084(US10611777, Compound 31 | (S)-4-amino-6-((1-(3-chl...)
Affinity DataIC50: 371nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent