BDBM436100 4-(((3S,4R)-1- ((2-chloro-4- (trifluoromethyl) phenyl)sulfonyl)- 4-hydroxy-4- (hydroxymethyl) pyrrolidin-3- yl)methyl) benzonitrile::US10590077, Example 2

SMILES OC[C@]1(O)CN(C[C@@H]1Cc1ccc(cc1)C#N)S(=O)(=O)c1ccc(cc1Cl)C(F)(F)F

InChI Key InChIKey=QQPLUCKOAQUILN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436100   

TargetTransient receptor potential cation channel subfamily V member 4(Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM436100(US10590077, Example 2 | 4-(((3S,4R)-1- ((2-chloro-...)
Affinity DataIC50: 55nMAssay Description:TRPV4 channel activation results in an influx of divalent and monovalent cations including calcium. The resulting changes in intracellular calcium we...More data for this Ligand-Target Pair
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Date in BDB:
12/7/2020
Entry Details
US Patent