BDBM436131 (S)-N4-(1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyrimidine-4,6-diamine::US10611777, Compound 81

SMILES C[C@H](Nc1ncnc(N)c1C(=O)NNC(C)=O)c1cc2ncc(Cl)n2nc1-c1ccccc1

InChI Key InChIKey=CJHYSTAAWQXULJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436131   

LigandPNGBDBM436131(US10611777, Compound 81 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 2nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

LigandPNGBDBM436131(US10611777, Compound 81 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 98nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Hutchison Medipharma

US Patent
LigandPNGBDBM436131(US10611777, Compound 81 | (S)-N4-(1-(3-chloro-6-ph...)
Affinity DataIC50: 630nMAssay Description:PI3K kinases including p110α/p85α and p110γ were purchased from Invitrogen, p110δ/p85α and p110β/p85α were from Mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent