BDBM436237 Preparation of of individual diastereoisomers of 3-((6S,8R)-6-(2,6-difluoro-4-(1-(3-fluoropropyl)azetidin-3-ylamino)phenyl)-8-methyl-8,9-dihydro-3H-pyrazolo[4,3-f]isoquinolin-7(6H)-yl)-2-fluoro-2-methylpropan-1-ol::US10590130, Example 23::US10590130, Example 24::US10961241, Example 24

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@@H](c2c(F)cc(NC3CN(CCCF)C3)cc2F)N1CC(C)(F)CO

InChI Key InChIKey=HZEJTMIZKGGUNU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 436237   

TargetEstrogen receptor [307-554](Human)
AstraZeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 436237BDBM436237(Preparation of of individual diastereoisomers of 3...)
Affinity DataIC50: 10nMAssay Description:The assay was performed as follows with all reagent additions carried out using the Beckman Coulter BioRAPTR FRD microfluidic workstation:1. Acoustic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 436237BDBM436237(Preparation of of individual diastereoisomers of 3...)
Affinity DataIC50: 10nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEstrogen receptor [307-554](Human)
AstraZeneca

US Patent
LigandChemical structure of BindingDB Monomer ID 436237BDBM436237(Preparation of of individual diastereoisomers of 3...)
Affinity DataIC50: 15nMAssay Description:The assay was performed as follows with all reagent additions carried out using the Beckman Coulter BioRAPTR FRD microfluidic workstation:1. Acoustic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 436237BDBM436237(Preparation of of individual diastereoisomers of 3...)
Affinity DataIC50: 15nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent