BDBM436274 2,2-difluoro-3- ((6S,8R)-6-(4- ((1-(3- fluoropropyl)aze- tidin-3- yl)amino)-2- methoxyphenyl)- 8-methyl- 3,6,8,9- tetrahydro-7H- pyrazolo[4,3- f]isoquinolin- 7-yl)propan-1- ol::US10590130, Example 60

SMILES COc1cc(OC2CN(CCCF)C2)ccc1[C@H]1N(CC(F)(F)CO)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key InChIKey=FVPASTFQVKDSSX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 436274   

LigandPNGBDBM436274(US10590130, Example 60 | 2,2-difluoro-3- ((6S,8R)-...)
Affinity DataIC50: 4.70nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM436274(US10590130, Example 60 | 2,2-difluoro-3- ((6S,8R)-...)
Affinity DataIC50: 1.10E+4nMAssay Description:ER: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assay...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
US Patent