BDBM436677 (S or R)-{4-[(4-fluoro-2-methyl-1H- indol-5-yl)oxy]-5- methylpyrrolo[1,2-b]pyridazin-6- yl}(3-hydroxypyrrolidin-1- yl)methanone::US20260022125, Example 9.3B

SMILES Cc1cc2c(F)c(Oc3ccnn4cc(C(=O)N5CCC(O)C5)c(C)c34)ccc2[nH]1

InChI Key InChIKey=GRFZHYLZPGFLPM-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436677   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436677BDBM436677((S or R)-{4-[(4-fluoro-2-methyl-1H- indol-5-yl)oxy...)
Affinity DataEC50:  1.30nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent