BDBM436681 (R or S)-6-((6-(3-hydroxy-2,2- dimethylazetidine-1-carbonyl)-5- methylpyrrolo[1,2-b]pyridazin-4- yl)oxy)-N,2-dimethylbenzofuran- 3-carboxamide::US20260022125, Example 10.2B

SMILES CNC(=O)c1c(C)oc2cc(Oc3ccnn4cc(C(=O)N5CC(O)C5(C)C)c(C)c34)ccc12

InChI Key InChIKey=QVNUWFUEQNNWJR-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436681   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436681BDBM436681((R or S)-6-((6-(3-hydroxy-2,2- dimethylazetidine-1...)
Affinity DataEC50:  1.70nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent