BDBM436689 N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)phenyl]-3H-imidazo[4,5- b]pyridin-1-yl]acetamide::US10617676, Example 20::US11207298, Example 20

SMILES FC(F)(F)c1cccc(c1)-c1cnc2[nH]c(=O)n(CC(=O)NC3CC3)c2c1

InChI Key InChIKey=HNKBEWDWWSYVSP-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 436689   

TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]Ro25-6981 from rat GluN2B receptorMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2A expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50:  22nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2B(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50:  22nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured after 5 mins by Qpatch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50:  22nMAssay Description:NMDA receptors are ion channels that are highly permeable to Ca2+ ions, rendering it possible to monitor NMDA receptor function using cell-based calc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutamate receptor ionotropic, NMDA 1/2C(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM436689(N-Cyclopropyl-2-[2-oxo-6-[3-(trifluoromethyl)pheny...)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed