BDBM436698 1-{5-methyl-4-[(2-methyl- 1H-indol-5- yl)oxy]pyrrolo[1,2- b]pyridazine-6- carbonyl}azetidine-3- carbonitrile::US20260022125, Example 13.3

SMILES Cc1cc2cc(Oc3ccnn4cc(C(=O)N5CC(C#N)C5)c(C)c34)ccc2[nH]1

InChI Key InChIKey=CJXHUJLWZGUHAA-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436698   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436698BDBM436698(1-{5-methyl-4-[(2-methyl- 1H-indol-5- yl)oxy]pyrro...)
Affinity DataEC50:  1.10nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
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Date in BDB:
6/3/2026
Entry Details
US Patent