BDBM436728 6-{[6-(3-cyanoazetidine-1- carbonyl)-5-methylpyrrolo[1,2- b]pyridazin-4-yl]oxy}-N- (cyclopropylmethyl)-2-methyl- 1-benzofuran-3-carboxamide::US20260022125, Example 16.2

SMILES Cc1oc2cc(Oc3ccnn4cc(C(=O)N5CC(C#N)C5)c(C)c34)ccc2c1C(=O)NCC1CC1

InChI Key InChIKey=SHAJPXGVGCTTSM-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436728   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436728BDBM436728(6-{[6-(3-cyanoazetidine-1- carbonyl)-5-methylpyrro...)
Affinity DataEC50:  1.20nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent