BDBM436758 6-({6-[(2R,3S)-3-fluoro-2- methylazetidine-1-carbonyl]-5- methylpyrrolo[1,2-b]pyridazin- 4-yl}oxy)-2-methyl-N-(oxetan- 3-yl)-1-benzofuran-3- carboxamide::US20260022125, Example 16.31

SMILES Cc1oc2cc(Oc3ccnn4cc(C(=O)N5C[C@H](F)[C@H]5C)c(C)c34)ccc2c1C(=O)NC1COC1

InChI Key InChIKey=NDDRTNQILMKNND-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436758   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436758BDBM436758(6-({6-[(2R,3S)-3-fluoro-2- methylazetidine-1-carbo...)
Affinity DataEC50:  1.40nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent