BDBM436788 5-((6-((2R,3S)-3-fluoro- 2-methylazetidine-1- carbonyl)-5- methylpyrrolo[1,2- b]pyridazin-4-yl)oxy)-N- ((1S,2S)-2- hydroxycyclobutyl)-2- methyl-1H-indole-1- carboxamide::US20260022125, Example 20.2

SMILES Cc1c(C(=O)N2C[C@H](F)[C@H]2C)cn2nccc(Oc3ccc4c(c3)cc(C)n4C(=O)N[C@H]3CC[C@@H]3O)c12

InChI Key InChIKey=FXLCXRIUXCFKDH-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 436788   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 436788BDBM436788(5-((6-((2R,3S)-3-fluoro- 2-methylazetidine-1- carb...)
Affinity DataEC50:  0.630nMAssay Description:The enzymatic activity of hVEGFR2 was measured using the TR-FRET based Ulight assay (Revvity) which measures phosphorylation of a fluorescently tagge...More data for this Ligand-Target Pair
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Date in BDB:
6/3/2026
Entry Details
US Patent