BDBM436808 5-((S)-7-Amino-8-cyano-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidin]-4'-yl)-3-chloro-N,N-dimethyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine-2-carboxamide ::US20260022132, Compound 507b
SMILES CN(C)C(=O)c1nn2c(c1Cl)CN(c1nc(OC[C@@]34CCCN3C[C@H](F)C4)nc3c1CO[C@@]1(CCCc4ccc(N)c(C#N)c41)C3)CCC2
InChI Key InChIKey=UVCFFLFDHUHSQW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 436808
Affinity DataKd: 0.0580nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
Affinity DataKd: 0.110nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences
US Patent
Treeline Biosciences
US Patent
Affinity DataIC50: 2.90nMAssay Description:Table B1: KRas G12V: Compounds were pre-dispensed via Echo liquid handling (acoustic, touch-free) to generate assay ready plates (ARP). More precisel...More data for this Ligand-Target Pair