BDBM436910 US20260022132, Compound 584a

SMILES Cc1c(C(=O)N(C)C)nn2c1CN(c1nc(OC[C@@]34CCCN3CC(F)(F)C4)nc3c1CO[C@@]1(CC[C@H](C)c4ccc(N)c(C#N)c41)C3)CCC2

InChI Key InChIKey=VLNBTPXKAQJHJE-UHFFFAOYSA-N

Data  1 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 436910   

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436910BDBM436910(US20260022132, Compound 584a)
Affinity DataKd:  0.0880nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

TargetGTPase KRas [G12V](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436910BDBM436910(US20260022132, Compound 584a)
Affinity DataKd:  0.25nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent

TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 436910BDBM436910(US20260022132, Compound 584a)
Affinity DataIC50: 2.5nMAssay Description:Table B1: KRas G12V: Compounds were pre-dispensed via Echo liquid handling (acoustic, touch-free) to generate assay ready plates (ARP). More precisel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2026
Entry Details
US Patent