BDBM436927 (1S,4S)-7-Amino-2'-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-4-methyl-4'-(6-oxa-1-azaspiro[3.4]octan-1-yl)-3,4,5',8'-tetrahydro-2H-spiro[naphthalene-1,7'-pyrano[4,3-d]pyrimidine]-8-carbonitrile ::US20260022132, Compound 598a
SMILES C[C@H]1CC[C@]2(Cc3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc(N4CCC45CCOC5)c3CO2)c2c1ccc(N)c2C#N
InChI Key InChIKey=DGUONHWWQZQJLK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 436927
Affinity DataKd: 0.0870nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
Affinity DataKd: 0.190nMAssay Description:Table B2: Biacore 8K buffer line was placed into 1 L of Immobilization buffer (20 mM HEPES pH 7.5/150 mM NaCl/5 mM MgCl2/0.5 mM TCEP/0.005% P20/500 n...More data for this Ligand-Target Pair
TargetGTPase KRas [1-169,G12V]/Son of sevenless homolog 1 [564-1049](Human)
Treeline Biosciences
US Patent
Treeline Biosciences
US Patent
Affinity DataIC50: 3.70nMAssay Description:Table B1: KRas G12V: Compounds were pre-dispensed via Echo liquid handling (acoustic, touch-free) to generate assay ready plates (ARP). More precisel...More data for this Ligand-Target Pair